Cryptogenic Stroke Initiative
In about 1 in 4 Ischemic Strokes, the root cause is still unknown after testing.
That's why it's important to dig deeper for a definitive diagnosis. Collaboration by neurologists, cardiologists, electrophysiologists and other integral team members may reveal the answers needed to provide targeted treatment for preventing recurrent strokes. Our tools are here to help.

Healthcare Professional Resources
Patient Education Resources
Potential Causes
It's important to consider conditions including (but not limited to):
- Atrial fibrillation (AF or Afib) – an irregular heartbeat that puts the patient at a 5x greater risk for stroke. Afib may be detected by monitoring the heart's rhythm over time.
- Patent Foramen Ovale (PFO) – a hole between the heart's chambers that usually closes naturally by adulthood.
- Thrombophilias – blood clotting disorders.
- Large-artery atherosclerosis – a buildup of fats, cholesterol and other substances in and on artery walls.
Diagnosis and Treatment
With limited guidelines, many professionals diagnose and treat cryptogenic stroke differently. We've developed resources that can help professionals team up to potentially find the causes, so patients can receive the most targeted treatment for preventing recurring strokes.
Stroke Resource Library
Steps to Help Avoid Another Stroke
Supports the American Heart Association/American Stroke Association's Cryptogenic Stroke Initiative.