The heart isn't particularly vulnerable to cancer – and here's why

By American Heart Association News

(Kateryna Kon/Science Photo Library, Getty Images)
(Kateryna Kon/Science Photo Library, Getty Images)

For years, Jan H. Mitchell felt terrible.

"The fatigue I was experiencing was unreal," said Mitchell, 62, of Paris, Tennessee. "It was beyond feeling tired; I would come home from work and had no energy to do anything."

Mitchell saw doctor after doctor. After a stress test, a sleep apnea assessment and other evaluations, one doctor sent her for a CT scan of her gallbladder. That's when the imaging technician spotted a tumor – in her heart.

The tumor was the size of a racquetball. Mitchell had immediate open-heart surgery to remove it in March 2009.

Even though heart disease tops the list of the nation's leading causes of death – ahead of cancer at No. 2 – heart cancer is quite rare. One study suggests primary cardiac tumors – those that develop in the heart itself – affect 1.38 in 100,000 people each year.

"A heart surgeon may only experience one during his entire career, if ever," said Dr. Monika Leja, a cardio-oncology specialist at the University of Michigan Frankel Cardiovascular Center in Ann Arbor, Michigan.

Heart cancer survivor Jan H. Mitchell.
Jan Mitchell developed atrial fibrillation after having a benign tumor removed from her heart. (Photo courtesy of Jan Mitchell)

Most heart tumors – about 75 percent – are benign, meaning they are not cancerous. Cancer that spreads to the heart from the lung, breast or elsewhere in the body is much more common. But when tumors begin in the heart, they "are likely a result of genetic malformations, since the heart is not a common place for cancers to grow," Leja said.

That's because of the heart's composition, said Dr. Scott Schuetze, director of the connective tissue oncology program at the University of Michigan Comprehensive Cancer Center in Ann Arbor.

The heart is made up of connective tissue, and cancer of that tissue is rare, Schuetze said. Rather, cancer more often arises in epithelial tissue that lines organs such as the prostate, breast, colon, pancreas, stomach, esophagus and skin.

Instead, "the heart is prone to disease that affects blood vessels, such as atherosclerotic disease and hypertension, because the heart is extremely dependent on blood flow for the work it does," Schuetze said.

The heart also is susceptible, he said, to diseases that affect muscle or pumping function, as well as conditions that affect its electrical system.

Because most heart tumors are benign, they are usually curable with surgery, said Dr. Michael Reardon, a cardiothoracic surgeon at Houston Methodist Hospital.

Without surgery, "the tumors can cause problems because pieces of them can break off and cause strokes," said Reardon.

Malignant heart tumors are treated with chemotherapy or surgery, or sometimes both depending on the type of tumor.

For Mitchell, surgery to remove the benign tumor caused her to develop a type of irregular heartbeat called atrial fibrillation. Because the condition can cause blood clots, she was treated with a device to prevent them from traveling to the brain and causing a stroke.

It has given the retired teacher peace of mind as she spends time with her husband, Joe, and their great-nieces and great-nephew. "Park time is their favorite."

If you have questions or comments about this story, please email [email protected].

American Heart Association News Stories

American Heart Association News covers heart disease, stroke and related health issues. Not all views expressed in American Heart Association News stories reflect the official position of the American Heart Association. Statements, conclusions, accuracy and reliability of studies published in American Heart Association scientific journals or presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect the American Heart Association’s official guidance, policies or positions.

Copyright is owned or held by the American Heart Association, Inc., and all rights are reserved. Permission is granted, at no cost and without need for further request, for individuals, media outlets, and non-commercial education and awareness efforts to link to, quote, excerpt from or reprint these stories in any medium as long as no text is altered and proper attribution is made to American Heart Association News.

Other uses, including educational products or services sold for profit, must comply with the American Heart Association’s Copyright Permission Guidelines. See full terms of use. These stories may not be used to promote or endorse a commercial product or service.

HEALTH CARE DISCLAIMER: This site and its services do not constitute the practice of medical advice, diagnosis or treatment. Always talk to your health care provider for diagnosis and treatment, including your specific medical needs. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately. If you are in the United States and experiencing a medical emergency, call 911 or call for emergency medical help immediately.