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Managing Uncontrollable Bleeding Attributed to Anticoagulant Therapy: Stroke Clinical Update

anticoagulant bleeding issuesProgram Overview

Atrial Fibrillation (AFib) is a growing health problem, an under-treated disease, and a significant risk factor for stroke. Although oral anticoagulants have shown a concrete evidence for reducing strokes by over 60%, current recommended treatment with oral anticoagulants has plateaued at around 50% of eligible patients. Anticoagulation with warfarin is associated with the risk of hemorrhage; time consuming and inconvenient monitoring requirements; and challenges in physician evaluation of the risks and benefits of anticoagulation due to comorbidities in AFib patients.

New approved anticoagulants have decreased the need for monitoring for hemorrhage risk. On the contrary, when hemorrhage does occur with the use of new anticoagulants the ability to immediately medically reverse the bleeding has been very limited. Clinical studies are underway to identify new agents for the reversal of the effects of anticoagulation when sudden uncontrollable bleeding occurs.

Purpose Statement

To increase clinician knowledge on how to manage uncontrollable bleeding attributed to anticoagulant therapy.

Goals and Learning Objectives

  • Identify the use of anticoagulation in stroke patients.
  • Examine the risk of bleeding associated with anticoagulation therapy.
  • Explain how low risk stroke patients with AFib, using anticoagulation, are at a greater risk for uncontrollable bleeding.
  • Discuss new agents to reverse the effects of anticoagulants when bleeding occurs.

Target Audience

The target audience for Managing Uncontrollable Bleeding Attributed to Anticoagulant Therapy includes neurologists, neuroscience nurses, health care professionals, and other professionals who work in stroke care.

Content Developed and Presented By

Philip B. Gorelick,  MD, MPH, FACP, FAAN, FANA, FAHA
Medical Director, Mercy Health Hauenstein Neurosciences
Professor, Department of Translational Science & Molecular Medicine

Muhammad U. Farooq, MD, FACP, FAHA
Division of Stroke and Vascular Neurology, Mercy Health Hauenstein Nuerosciences

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